Association of LEPR Gln223Arg polymorphism with T2DM: A meta-analysis

Diabetes Res Clin Pract. 2015 Sep;109(3):e21-6. doi: 10.1016/j.diabres.2015.05.042. Epub 2015 May 30.

Abstract

A meta-analysis was conducted to evaluate the association of LEPR Gln223Arg polymorphism with type 2diabetes (T2DM). Sixteen individual studies with 7827 subjects were included into the meta-analysis. Current studies suggest that LEPR Gln223Arg polymorphism may not affect the susceptibility with type 2diabetes (T2DM).

Keywords: Gln223Arg; LEPR; Meta-analysis; T2DM.

Publication types

  • Meta-Analysis
  • Review

MeSH terms

  • Amino Acid Substitution
  • Arginine / genetics
  • Diabetes Mellitus, Type 2 / epidemiology
  • Diabetes Mellitus, Type 2 / genetics*
  • Genetic Association Studies / statistics & numerical data
  • Genetic Predisposition to Disease
  • Glutamine / genetics
  • Humans
  • Polymorphism, Single Nucleotide
  • Receptors, Leptin / genetics*

Substances

  • LEPR protein, human
  • Receptors, Leptin
  • Glutamine
  • Arginine