Current laboratory investigation of patients with suspected immunodeficiency or immune-mediated disease includes extensive analysis of lymphocyte subsets, T-cell receptor use, antibody profiles, cytokine profiles and genetic polymorphisms of relevant genes, all in all: big data. Clinical immunology clearly has entered the omics era, generating more and more data.
Keywords: antibody response; bioinformatics; clinical immunology; data mining; phenotyping; vaccination.