[Systemic lupus erythematosus presenting as Stevens-Johnson syndrome]

Pathol Biol (Paris). 2015 Sep;63(4-5):222-3. doi: 10.1016/j.patbio.2015.05.001. Epub 2015 Jun 15.
[Article in French]

Abstract

Stevens-Johnson syndrome and toxic epidermal necrolysis are life-threatening dermatological conditions. Their most common cause is medication. However, in a small proportion of patients these dermatological conditions could be the first presentation of systemic lupus erythematosus. We now describe a 34-year-old patient who presented with manifestations of Stevens-Johnson as a first feature of systemic lupus erythematosus. Systemic lupus erythematosus reveled by Stevens-Johnson syndrome has been infrequently reviewed in the previous literature. This diagnosis should be considered when cutaneous adverse drug reactions occur without clear drug causality.

Keywords: Lupus erythematosus; Lupus érythémateux systémique; Nécrolyse épidermique toxique; Stevens-Johnson syndrome; Syndrome de Stevens-Johnson; Toxic epidermal necrolysis.

Publication types

  • Case Reports
  • English Abstract

MeSH terms

  • Adult
  • Anemia / etiology
  • Arthralgia / etiology
  • Autoantibodies / blood
  • Complement C3 / analysis
  • Critical Care
  • Facial Dermatoses / etiology
  • Female
  • Humans
  • Hydroxychloroquine / therapeutic use
  • Immunoglobulin G / analysis
  • Lupus Erythematosus, Systemic / blood
  • Lupus Erythematosus, Systemic / complications*
  • Lupus Erythematosus, Systemic / diagnosis
  • Lupus Erythematosus, Systemic / drug therapy
  • Lupus Erythematosus, Systemic / immunology
  • Methylprednisolone / therapeutic use
  • Mucositis / etiology
  • Prednisone / therapeutic use
  • Stevens-Johnson Syndrome / drug therapy
  • Stevens-Johnson Syndrome / etiology*

Substances

  • Autoantibodies
  • Complement C3
  • Immunoglobulin G
  • Hydroxychloroquine
  • Prednisone
  • Methylprednisolone