Background: Endometriosis is a gynecological disorder that is associated with alterations in the immune system that contributes to its pathology as well as its associated infertility.
Main findings: This brief report summarizes our findings related to the changes in T regulatory cells (Tregs) that may affect the uterine environment and impact the fertility of women and nonhuman primates with endometriosis.
Principal conclusion: Targeted therapies that could reduce Tregs within the reproductive tract may have a potential as long-lasting or permanent contraception.
Keywords: Endometriosis; Immune cells; Inflammation; Uterine environment.
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