Abstract
Epstein-Barr-related herpesviruses, or lymphocryptoviruses (LCV), naturally infect humans and nonhuman primates (NHP), but their host range is not well characterized. Using LCV and B cells from multiple species of Hominidae and Cercopithecidae, we show that LCV can immortalize B cells from some nonnative species but that growth transformation is restricted to B cells from their own family of hominoids or Old World NHP, suggesting a high degree of LCV adaptation to their natural primate host.
Copyright © 2015, American Society for Microbiology. All Rights Reserved.
MeSH terms
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Amino Acid Sequence
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Animals
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B-Lymphocytes / immunology
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B-Lymphocytes / virology
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Base Sequence
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Cercopithecidae / immunology
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Cercopithecidae / virology*
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Epstein-Barr Virus Nuclear Antigens / genetics
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Herpesviridae Infections / pathology
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Herpesviridae Infections / virology
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Herpesvirus 4, Human / pathogenicity*
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Host Specificity*
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Humans
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Lymphocryptovirus / pathogenicity*
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Molecular Sequence Data
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Monkey Diseases / virology*
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Sequence Alignment
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Sequence Analysis, DNA
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Viral Proteins / genetics
Substances
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EBNA-2 protein, Human herpesvirus 4
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Epstein-Barr Virus Nuclear Antigens
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Viral Proteins
Associated data
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GENBANK/KT072774
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GENBANK/KT072775
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GENBANK/KT072776