The inner and outer of our thorax: silicone breast implants and pulmonary alveolar proteinosis

Acta Clin Belg. 2015 Oct;70(5):384-6. doi: 10.1179/2295333715Y.0000000035. Epub 2015 Jun 17.

Abstract

Pulmonary alveolar (phospholipo)proteinosis (PAP) is a rare lung disease, predominantly autoimmune in nature. This case report describes a patient with insidious dyspnoea since 5 years and a milky appearance of her bronchoalveolar fluid, leading to the diagnosis of PAP. The onset of symptoms coincided with an exchange of her silicone breast implants. Giant cell reaction in axillary adenopathies pointed towards silicone leakage. Adjuvants, such as silicone, might boost pre-existing antigen reactions of the immune system, potentially leading to autoimmune phenomena.

Keywords: Autoimmune/inflammatory; Autoimmunity; Pulmonary alveolar proteinosis; Silicone; Syndrome induced by adjuvants.

Publication types

  • Case Reports

MeSH terms

  • Autoimmune Diseases / diagnosis*
  • Autoimmune Diseases / etiology
  • Breast Implants / adverse effects*
  • Female
  • Granuloma, Giant Cell / pathology
  • Humans
  • Middle Aged
  • Pulmonary Alveolar Proteinosis / diagnosis*
  • Pulmonary Alveolar Proteinosis / etiology
  • Silicone Gels / adverse effects*

Substances

  • Silicone Gels

Supplementary concepts

  • Pulmonary Alveolar Proteinosis, Acquired