Chemical constituents of Abies fabri

Yong-Li Li; Yan-Xia Gao; Hui-Zi Jin; Lei Shan; Wan-Lin Chang; Xian-Wen Yang; Hua-Wu Zeng; Ning Wang; Andre Steinmetz; Wei-Dong Zhang

doi:10.1016/j.phytochem.2015.06.012

Chemical constituents of Abies fabri

Phytochemistry. 2015 Sep:117:135-143. doi: 10.1016/j.phytochem.2015.06.012. Epub 2015 Jun 12.

Authors

Yong-Li Li¹, Yan-Xia Gao², Hui-Zi Jin², Lei Shan³, Wan-Lin Chang³, Xian-Wen Yang⁴, Hua-Wu Zeng³, Ning Wang⁵, Andre Steinmetz⁵, Wei-Dong Zhang⁶

Affiliations

¹ School of Pharmacy, Shanghai JiaoTong University, 800 Dongchuan Road, Shanghai 200240, China; Division of Material Science & Quality Test, Shanghai Institute of Measurement and Testing Technology, Shanghai 201203, China.
² School of Pharmacy, Shanghai JiaoTong University, 800 Dongchuan Road, Shanghai 200240, China.
³ School of Pharmacy, Second Military Medical University, 325 Guohe Road, Shanghai 200433, China.
⁴ School of Pharmacy, Second Military Medical University, 325 Guohe Road, Shanghai 200433, China; Laboratory of Cellular and Molecular Oncology, Luxembourg Institute of Health, 84 Val Fleuri, L-1526 Luxembourg, Luxembourg. Electronic address: xianwen.yang@lih.lu.
⁵ Laboratory of Cellular and Molecular Oncology, Luxembourg Institute of Health, 84 Val Fleuri, L-1526 Luxembourg, Luxembourg.
⁶ School of Pharmacy, Shanghai JiaoTong University, 800 Dongchuan Road, Shanghai 200240, China; School of Pharmacy, Second Military Medical University, 325 Guohe Road, Shanghai 200433, China. Electronic address: wdzhangy@hotmail.com.

PMID: 26083453
DOI: 10.1016/j.phytochem.2015.06.012

Abstract

Systematic phytochemical investigations on Abies fabri resulted in the isolation of 94 compounds, consisting of 68 terpenoids, six lignans, seven flavonoids, and 13 other miscellaneous chemical constituents. Their structures were elucidated on the basis of spectroscopic methods, and the absolute configurations of three of these previously unknown compounds were determined by Cu-Kα X-ray crystallographic analysis. Twelve previously unreported compounds, one artifact, and one potential artifact were identified, including six triterpenoids, four diterpenoids, two sesquiterpenoids, one lignan, and one phenol. 23-Hydroxy-3-oxolanosta-8,24-dien-26,23-olide showed weak cytotoxic activity against A549 and THP-1 cells with the IC50 values of 5.3 and 5.1 μM, respectively.

Keywords: Abies fabri; Cu-Kα X-ray crystallography; Cytotoxicity; Diterpenoids; Pinaceae; Triterpenoids.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Abies / chemistry*
Antineoplastic Agents, Phytogenic* / chemistry
Antineoplastic Agents, Phytogenic* / isolation & purification
Antineoplastic Agents, Phytogenic* / pharmacology
Crystallography, X-Ray
Diterpenes / chemistry
Drugs, Chinese Herbal* / chemistry
Drugs, Chinese Herbal* / isolation & purification
Drugs, Chinese Herbal* / pharmacology
Flavonoids / chemistry
Inhibitory Concentration 50
Lignans / chemistry
Lipopolysaccharides / pharmacology
Macrophages / drug effects
Molecular Conformation
Molecular Structure
Nitric Oxide / biosynthesis
Nuclear Magnetic Resonance, Biomolecular
Phenols / chemistry
Phenols / isolation & purification
Phenols / pharmacology
Plant Components, Aerial / chemistry
Plant Extracts / chemistry
Terpenes / analysis
Triterpenes / chemistry

Substances

Antineoplastic Agents, Phytogenic
Diterpenes
Drugs, Chinese Herbal
Flavonoids
Lignans
Lipopolysaccharides
Phenols
Plant Extracts
Terpenes
Triterpenes
Nitric Oxide