Elastic sealants for surgical applications

Nasim Annabi; Kan Yue; Ali Tamayol; Ali Khademhosseini

doi:10.1016/j.ejpb.2015.05.022

Elastic sealants for surgical applications

Eur J Pharm Biopharm. 2015 Sep;95(Pt A):27-39. doi: 10.1016/j.ejpb.2015.05.022. Epub 2015 Jun 12.

Authors

Nasim Annabi¹, Kan Yue², Ali Tamayol², Ali Khademhosseini³

Affiliations

¹ Department of Chemical Engineering, Northeastern University, Boston, MA 02115-5000, USA; Biomaterials Innovations Research Center, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, USA; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA.
² Biomaterials Innovations Research Center, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, USA.
³ Biomaterials Innovations Research Center, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, USA; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA; Department of Biomedical Engineering, The University of Texas at Austin, Austin, TX, USA; Department of Physics, King Abdulaziz University, Jeddah 21569, Saudi Arabia. Electronic address: alik@rics.bwh.harvard.edu.

Abstract

Sealants have emerged as promising candidates for replacing sutures and staples to prevent air and liquid leakages during and after the surgeries. Their physical properties and adhesion strength to seal the wound area without limiting the tissue movement and function are key factors in their successful implementation in clinical practice. In this contribution, the advances in the development of elastic sealants formed from synthetic and natural materials are critically reviewed and their shortcomings are pointed out. In addition, we highlight the applications in which elasticity of the sealant is critical and outline the limitations of the currently available sealants. This review will provide insights for the development of novel bioadhesives with advanced functionality for surgical applications.

Keywords: Adhesion; Elasticity; Hydrogel; Surgical applications; Surgical sealants; Tissue adhesives.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

MeSH terms

Albumins / administration & dosage
Animals
Elasticity*
Fibrin Tissue Adhesive / administration & dosage
Humans
Tissue Adhesions / pathology
Tissue Adhesions / surgery*
Tissue Adhesives / administration & dosage*

Substances

Albumins
Fibrin Tissue Adhesive
Tissue Adhesives

Abstract

Publication types

MeSH terms

Substances

Grants and funding