Conjugate products of pyocyanin-glutathione reactions

Rajkumar Cheluvappa; Rajaraman Eri

doi:10.1016/j.cbi.2015.06.002

Conjugate products of pyocyanin-glutathione reactions

Chem Biol Interact. 2015 Aug 5:238:91-2. doi: 10.1016/j.cbi.2015.06.002. Epub 2015 Jun 12.

Authors

Rajkumar Cheluvappa¹, Rajaraman Eri²

Affiliations

¹ Department of Medicine, St. George Clinical School, University of New South Wales, Sydney, NSW, Australia. Electronic address: rajkumarchel@gmail.com.
² Mucosal Biology Laboratory, School of Human Life Sciences, University of Tasmania, Launceston, TAS, Australia.

PMID: 26079058
DOI: 10.1016/j.cbi.2015.06.002

Abstract

This "Letter to the Editor" is a "gentle but purposeful rejoinder" to specific comments made in pages 36-37 of your Muller and Merrett (2015) publication regarding the data presented in our Cheluvappa et al. (2008) paper. Our rebuttal topics include the effect of oxygen on the pyocyanin-glutathione reaction, relevance of reaction-duration to pathophysiology, rationale of experiments, veracity of statements germane to molecular-structure construction, and correction of hyperbole.

Keywords: Catalase; Conjugate; Glutathione; Hydrogen peroxide; Pyocyanin; Superoxide dismutase.

Publication types

Letter
Comment

MeSH terms

Glutathione / pharmacology*
Humans
Pyocyanine / chemistry*
Pyocyanine / toxicity*

Substances

Pyocyanine
Glutathione