Prophylactic oophorectomy for hereditary small cell carcinoma of the ovary, hypercalcemic type

Andrew Berchuck; Leora Witkowski; Martin Hasselblatt; William D Foulkes

doi:10.1016/j.gore.2015.02.002

Prophylactic oophorectomy for hereditary small cell carcinoma of the ovary, hypercalcemic type

Gynecol Oncol Rep. 2015 Feb 25:12:20-2. doi: 10.1016/j.gore.2015.02.002. eCollection 2015 Apr.

Authors

Andrew Berchuck¹, Leora Witkowski², Martin Hasselblatt³, William D Foulkes²

Affiliations

¹ Duke University Medical Center, Durham, NC, United States.
² Department of Human Genetics, McGill University, Montreal, QC, Canada.
³ Institute of Neuropathology, University Hospital Münster, Germany.

Abstract

•Prophylactic oophorectomy can prevent small cell carcinoma of the ovary, hypercalcemic type in carriers of germline SMARCA4 mutations.•Unaffected SMARCA4 mutation carriers who desire children may be best served by oocyte cryopreservation prior to prophylactic oophorectomy.

Keywords: Ovarian cancer; Prophylactic oophorectomy; SMARCA4 mutation.

Publication types

Case Reports