Four new phenolic acid with unusual bicycle [2.2.2] octane moiety from Clerodendranthus spicatus and their anti-inflammatory activity

Fitoterapia. 2015 Sep:105:61-5. doi: 10.1016/j.fitote.2015.06.010. Epub 2015 Jun 12.

Abstract

Four new phenolic acids, clerodens A-D (1-4) possessing an unusual bicycle [2.2.2] octane moiety were isolated from the whole plants of Clerodendranthus spicatus. Their structures were elucidated by extensive spectroscopic methods, including NMR, MS, and ECD data. All isolates were evaluated for their anti-inflammatory activities on lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW 264.7, and compound 4 showed significant inhibitory activities with IC50 value of 6.8 μM.

Keywords: Anti-inflammatory; Clerodendranthus spicatus; Phenolic acids.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anti-Inflammatory Agents / chemistry*
  • Anti-Inflammatory Agents / isolation & purification
  • Hydroxybenzoates / chemistry*
  • Hydroxybenzoates / isolation & purification
  • Inhibitory Concentration 50
  • Lamiaceae / chemistry*
  • Mice
  • Molecular Structure
  • Nitric Oxide / metabolism
  • Octanes / chemistry*
  • Octanes / isolation & purification
  • RAW 264.7 Cells

Substances

  • Anti-Inflammatory Agents
  • Hydroxybenzoates
  • Octanes
  • Nitric Oxide
  • phenolic acid