Successful Treatment with Infliximab for Refractory Uveitis in a Hemodialysis Patient with Behçet's Disease and a Review of the Literature for Infliximab Use in Patients on Hemodialysis

Intern Med. 2015;54(12):1553-7. doi: 10.2169/internalmedicine.54.4274. Epub 2015 Jun 15.

Abstract

A 36-year-old man with a 16-year history of refractory Behçet's disease (BD)-associated uveitis and chronic renal failure requiring hemodialysis suffered from frequent ocular attacks despite treatment with systemic corticosteroids and cyclosporine A. Following infliximab administration, the patient's BD ocular attack score 24 and visual acuity improved. Although he developed mild acute gastroenteritis, he did not experience any other adverse events. In our review of the literature, we identified seven patients on hemodialysis with inflammatory disease successfully treated with infliximab. Infliximab may be effective and safe in cases of BD and other diseases, including in patients under hemodialysis.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adrenal Cortex Hormones / administration & dosage*
  • Adult
  • Behcet Syndrome / drug therapy*
  • Behcet Syndrome / immunology
  • Cyclosporine / therapeutic use
  • Dose-Response Relationship, Drug
  • Glucocorticoids / administration & dosage*
  • Humans
  • Infliximab / therapeutic use*
  • Male
  • Renal Dialysis*
  • Treatment Outcome
  • Uveitis / drug therapy*
  • Uveitis / immunology
  • Visual Acuity

Substances

  • Adrenal Cortex Hormones
  • Glucocorticoids
  • Cyclosporine
  • Infliximab