[Suicide attempt by means of phenobarbital overdose. Effective treatment with continuous veno-venous hemodialysis]

Med Klin Intensivmed Notfmed. 2016 Mar;111(2):141-4. doi: 10.1007/s00063-015-0046-7. Epub 2015 Jun 13.
[Article in German]

Abstract

A 68-year-old woman tried to commit suicide using phenobarbital, which was initially prescribed for her dog that suffered from seizures. At admission she was unconscious and ventilated. Five days of intensive care therapy did not improve her state of consciousness. Subsequent continuous veno-venous hemodialysis accelerated the elimination of phenobarbital compared to endogenous elimination by a factor of five. The patient survived without sequelae. Detailed history taking and well-timed indication for dialysis were crucial.

Keywords: Anticonvulsants; Barbiturates; Coma; Electroencephalography; Veterinary drugs.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Anticonvulsants / pharmacokinetics
  • Anticonvulsants / poisoning*
  • Female
  • Hemofiltration*
  • Humans
  • Intensive Care Units
  • Metabolic Clearance Rate / physiology
  • Phenobarbital / pharmacokinetics
  • Phenobarbital / poisoning*
  • Suicide, Attempted*

Substances

  • Anticonvulsants
  • Phenobarbital