Incidence of primary breast cancer in Iran: Ten-year national cancer registry data report

Seyed Behzad Jazayeri; Soheil Saadat; Rashid Ramezani; Ahmad Kaviani

doi:10.1016/j.canep.2015.04.016

Incidence of primary breast cancer in Iran: Ten-year national cancer registry data report

Cancer Epidemiol. 2015 Aug;39(4):519-27. doi: 10.1016/j.canep.2015.04.016. Epub 2015 Jun 10.

Authors

Seyed Behzad Jazayeri¹, Soheil Saadat², Rashid Ramezani³, Ahmad Kaviani⁴

Affiliations

¹ Sina Trauma and Surgery Research Center, Tehran University of Medical Sciences, Tehran, Iran; Students' Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran.
² Sina Trauma and Surgery Research Center, Tehran University of Medical Sciences, Tehran, Iran; Department of e-Health, Virtual School, Tehran University of Medical Sciences, Tehran, Iran.
³ Ministry of Health, Center for Disease Control and Prevention, Non-communicable Diseases Unit, Cancer Office, Tehran, Iran.
⁴ Department of Surgery, Tehran University of Medical Sciences, Tehran, Iran; Department of Research, Kaviani Breast Diseases Institute, Tehran, Iran. Electronic address: akaviani@tums.ac.ir.

PMID: 26070507
DOI: 10.1016/j.canep.2015.04.016

Abstract

Breast cancer is the leading type of malignancy and the leading cause of cancer-related deaths in women worldwide. The screening programs and advances in the treatment of patients with breast cancer have led to an increase in overall survival. Cancer registry systems play an important role in providing basic data for research and the monitoring of the cancer status. In this study, the results of the 10-year national cancer registry (NCR) of Iran in breast cancer are reviewed. NCR database records were searched for primary breast cancer records according to ICD-O-3 coding and the cases were reviewed. A total of 52,068 cases were found with the coding of primary breast cancer. Females constituted 97.1% of the cases. Breast cancer was the leading type of cancer in Iranian females, accounting for 24.6% of all cancers. The mean age of the women with breast cancer was 49.6 years (95%CI 49.5-49.6). Most of the cases (95.7%) were registered as having invasive pathologies (behavior code 3). The most common morphology of primary breast cancer was invasive ductal carcinoma (ICD-O 8500/3) followed by invasive lobular carcinoma (ICD-O 8520/3) with relative frequencies of 77.8% and 5.2%, respectively. The average annual crude incidence of primary breast cancer in females was 22.6 (95%CI 22.1-23.1) per 100,000 females, with an age-standardized rate (ASR) of 27.4 (95%CI 22.5-35.9). There were no data on survival, staging or immunohistochemical marker(s) of the breast-cancer-registered cases. The incidence of breast cancer in Iran is lower than in low-middle-income neighboring countries. The NCR data registry of breast cancer is not accurate in monitoring the effect of screening programs or determining the current status of breast cancer in Iran. Screening programs of breast cancer in Iran have failed to enhance the detection of the patients with in situ lesion detection. A quality breast cancer registry and a screening program for breast cancer are both needed.

Keywords: Breast cancer; Cancer registry; Invasive ductal carcinoma; Iran.

MeSH terms

Adult
Breast Neoplasms / epidemiology*
Breast Neoplasms, Male / epidemiology*
Female
Humans
Incidence
Iran / epidemiology
Male
Middle Aged
Registries