Proton pump inhibitor-induced hypomagnesemic hypoparathyroidism

Indian J Pharmacol. 2015 May-Jun;47(3):330-1. doi: 10.4103/0253-7613.157135.

Abstract

Proton pump inhibitors are the one of the most widely used drugs in the world. Hypomagnesemic hypoparathyroidism has been reported with different proton pump inhibitors with prolonged oral use. We report the first reported case of possible such effect with intravenous preparation of proton pump inhibitor. This case report raises awareness among physicians worldwide of this often unknown association, as life-threatening cardiac and neuromuscular complications can arise with unrecognized hypocalcemia and hypomagnesemia with proton pump inhibitors.

Keywords: Hypocalcemia; hypoparathyroidism; proton pump inhibitors; tetany.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Esomeprazole / adverse effects*
  • Female
  • Humans
  • Hypocalcemia / chemically induced*
  • Hypocalcemia / complications*
  • Hypoparathyroidism / chemically induced*
  • Hypoparathyroidism / complications*
  • Magnesium Deficiency / chemically induced
  • Magnesium Deficiency / complications
  • Magnesium Deficiency / congenital*
  • Proton Pump Inhibitors / adverse effects*

Substances

  • Proton Pump Inhibitors
  • Esomeprazole

Supplementary concepts

  • Hypomagnesemia 1, Intestinal