Nasal manifestations of IgG4-related disease: A report of two cases

Keiko Ohno; Yoko Matsuda; Tomio Arai; Yurika Kimura

doi:10.1016/j.anl.2015.05.004

Nasal manifestations of IgG4-related disease: A report of two cases

Auris Nasus Larynx. 2015 Dec;42(6):483-7. doi: 10.1016/j.anl.2015.05.004. Epub 2015 Jun 6.

Authors

Keiko Ohno¹, Yoko Matsuda², Tomio Arai², Yurika Kimura³

Affiliations

¹ Department of Otolaryngology, Tokyo Metropolitan Geriatric Hospital, Japan. Electronic address: takoto@tmd.ac.jp.
² Department of Pathology, Tokyo Metropolitan Geriatric Hospital, Japan.
³ Department of Otolaryngology, Tokyo Metropolitan Geriatric Hospital, Japan.

PMID: 26060132
DOI: 10.1016/j.anl.2015.05.004

Abstract

IgG4-related disease (IgG4-RD) is a recently recognized clinical disease entity characterized by elevated serum IgG4, tumefaction, tissue infiltration of IgG4-positive plasma cells and fibrosis. IgG4-RD may occur, either synchronously or metachronously, in a variety of organs throughout the body. We describe herein two representative cases of the nasal manifestations of IgG4-RD, characterized by diffuse, crusty, erosive lesions on nasal mucosa. Oral steroid administration was effective in treating these nasal manifestations. We report a decrease in IgG4 positive plasma cell infiltrates in nasal mucosa biopsy specimens after steroid therapy, demonstrating that infiltration of IgG4-positive cells is reversible.

Keywords: IgG4; IgG4-related disease; Immunoglobulin; Nasal manifestations; Rhinitis; Rhinosinusitis.

Publication types

Case Reports

MeSH terms

Adrenal Cortex Hormones / therapeutic use
Aged
Autoimmune Diseases / drug therapy
Autoimmune Diseases / immunology*
Autoimmune Diseases / pathology
Humans
Immunoglobulin G / immunology*
Male
Middle Aged
Nasal Mucosa / immunology*
Nasal Mucosa / pathology
Rhinitis / drug therapy
Rhinitis / immunology*
Rhinitis / pathology
Sinusitis / drug therapy
Sinusitis / immunology*
Sinusitis / pathology

Substances

Adrenal Cortex Hormones
Immunoglobulin G