Levitational Image Cytometry with Temporal Resolution

Savas Tasoglu; Joseph A Khoory; Huseyin C Tekin; Clemence Thomas; Antoine E Karnoub; Ionita C Ghiran; Utkan Demirci

doi:10.1002/adma.201405660

Levitational Image Cytometry with Temporal Resolution

Adv Mater. 2015 Jul 8;27(26):3901-8. doi: 10.1002/adma.201405660. Epub 2015 Jun 8.

Authors

Savas Tasoglu^{1

2}, Joseph A Khoory³, Huseyin C Tekin^{1

2}, Clemence Thomas⁴, Antoine E Karnoub⁴, Ionita C Ghiran³, Utkan Demirci^{1

2}

Affiliations

¹ Department of Radiology, Stanford School of Medicine, Demirci Bio-acoustic MEMS in Medicine (BAMM) Labs, Canary Center at Stanford for Cancer Early Detection, Palo Alto, CA, 94304, USA.
² Demirci BAMM Labs, Divisions of Biomedical Engineering Infectious Diseases, and Renal Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.
³ Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 02115, USA.
⁴ Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 02115, USA.

Abstract

A simple, yet powerful magnetic-levitation-based device is reported for real-time, label-free separation, as well as high-resolution monitoring of cell populations based on their unique magnetic and density signatures. This method allows a wide variety of cellular processes to be studied, accompanied by transient or permanent changes in cells' fundamental characteristics as a biological material.

Keywords: biological materials; cell screening; cell separation; cells; magnetic levitation.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Erythrocytes / cytology
Humans
Image Cytometry / instrumentation*
Magnetic Phenomena*
Microscopy, Fluorescence
Time Factors

Abstract

Publication types

MeSH terms

Grants and funding