High-intensity focused ultrasound (HIFU) for adenomyosis: Two-year follow-up results

Lian Shui; Shihua Mao; Qingrong Wu; Guohua Huang; Jian Wang; Ruitao Zhang; Kequan Li; Jia He; Lian Zhang

doi:10.1016/j.ultsonch.2015.05.024

High-intensity focused ultrasound (HIFU) for adenomyosis: Two-year follow-up results

Ultrason Sonochem. 2015 Nov:27:677-681. doi: 10.1016/j.ultsonch.2015.05.024. Epub 2015 May 27.

Authors

Lian Shui¹, Shihua Mao², Qingrong Wu³, Guohua Huang⁴, Jian Wang⁵, Ruitao Zhang⁶, Kequan Li⁴, Jia He⁷, Lian Zhang⁸

Affiliations

¹ State Key Laboratory of Ultrasound Engineering in Medicine Co-founded by Chongqing and the Ministry of Science and Technology, Chongqing Key Laboratory of Ultrasound in Medicine and Engineering, College of Biomedical Engineering, Chongqing Medical University, Chongqing 400016, PR China.
² Department of Obstetrics and Gynecology, Three Gorges Central Hospital, Chongqing 404000, PR China.
³ Department of Obstetrics and Gynecology, Fuling Central Hospital, Chongqing 408099, PR China.
⁴ State Key Laboratory of Ultrasound Engineering in Medicine Co-founded by Chongqing and the Ministry of Science and Technology, Chongqing Key Laboratory of Ultrasound in Medicine and Engineering, College of Biomedical Engineering, Chongqing Medical University, Chongqing 400016, PR China; Department of Obstetrics and Gynecology, Chongqing Haifu Hospital, Chongqing 401121, PR China.
⁵ State Key Laboratory of Ultrasound Engineering in Medicine Co-founded by Chongqing and the Ministry of Science and Technology, Chongqing Key Laboratory of Ultrasound in Medicine and Engineering, College of Biomedical Engineering, Chongqing Medical University, Chongqing 400016, PR China; Department of Obstetrics and Gynecology, Three Gorges Central Hospital, Chongqing 404000, PR China.
⁶ State Key Laboratory of Ultrasound Engineering in Medicine Co-founded by Chongqing and the Ministry of Science and Technology, Chongqing Key Laboratory of Ultrasound in Medicine and Engineering, College of Biomedical Engineering, Chongqing Medical University, Chongqing 400016, PR China; Department of Obstetrics and Gynecology, Fuling Central Hospital, Chongqing 408099, PR China.
⁷ Department of Obstetrics and Gynecology, Suining Central Hospital, Sichuan 629000, PR China. Electronic address: hejia0820@sina.com.cn.
⁸ State Key Laboratory of Ultrasound Engineering in Medicine Co-founded by Chongqing and the Ministry of Science and Technology, Chongqing Key Laboratory of Ultrasound in Medicine and Engineering, College of Biomedical Engineering, Chongqing Medical University, Chongqing 400016, PR China. Electronic address: lianwzhang@yahoo.com.

PMID: 26050604
DOI: 10.1016/j.ultsonch.2015.05.024

Abstract

Objective: To evaluate the long-term improvement of clinical symptoms of adenomyosis after treatment with ultrasound-guided high intensity focused ultrasound (USgHIFU).

Methods: From January 2010 to December 2011, 350 patients with adenomyosis were treated with USgHIFU. Among the 350 patients, 224 of them completed the two years follow-up. The patients were followed up at 3 months, 1 year, and 2 years after HIFU treatment. Adverse effects and complications were recorded.

Results: All patients completed HIFU ablation without severe postoperative complications. 203 of the 224 patients who showed varying degrees of dysmenorrhea before treatment had the symptom scores decreased significantly after treatment (P<0.001). The relief rate was 84.7%, 84.7%, and 82.3%, respectively at 3 months, 1 year, and 2 years after treatment. The menstrual volume in 109 patients with menorrhagia was significantly improved after treatment (P<0.001) with a relief rate of 79.8%, 80.7%, and 78.9%, respectively at 3 months, 1 year, and 2 years after HIFU treatment.

Conclusion: With its ability to sustain long-term clinical improvements, HIFU is a safe and effective treatment for adenomyosis.

Keywords: Adenomyosis; Adverse effect; Long-term follow-up; Ultrasound-guided high-intensity focused ultrasound.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adenomyosis / complications
Adenomyosis / physiopathology
Adenomyosis / surgery*
Adult
Dysmenorrhea / complications
Female
Follow-Up Studies
High-Intensity Focused Ultrasound Ablation* / adverse effects
Humans
Menstruation
Middle Aged
Treatment Outcome
Young Adult