An efficient synthesis and in vitro antibacterial evaluation of ruthenium-quinolinol complexes

Bioorg Med Chem Lett. 2015 Aug 1;25(15):2892-6. doi: 10.1016/j.bmcl.2015.05.063. Epub 2015 May 30.

Abstract

A series of ruthenium-quinolinol complexes were synthesized using a simple and effective pathway and their in vitro antibacterial activity against various resistant gram-positive and gram-negative bacteria were evaluated. It was established that compound [(η6-pcymene)RuCl(κ2-O,N-5,7-dibromo-HyQ)]·Cl (3b) & [(η6-pcymene)RuCl(κ2-O,N-5,7-dibromo-HyQ)]·Cl (3e) were significantly active against Staphylococcus aureus, Escherichia coli, Bacillus subtilis &Salmonella sp. The structures of the new compounds were elucidated by the analysis of spectroscopic data. The stability of complex [(η6-pcymene)RuCl(κ2-O,N-5,7-dibromo-HyQ)]·Cl (3b) was measured by UV spectroscopy & time dependent NMR spectroscopy. Compound 3b also shows remarkable fluorescence.

Keywords: Antibacterial assay; Fluorescent complex; Ruthenium–quinolinol complex.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / chemistry*
  • Anti-Bacterial Agents / pharmacology*
  • Bacillus subtilis / drug effects
  • Bacterial Infections / drug therapy
  • Coordination Complexes / chemical synthesis
  • Coordination Complexes / chemistry
  • Coordination Complexes / pharmacology
  • Escherichia coli / drug effects
  • Humans
  • Hydroxyquinolines / chemical synthesis
  • Hydroxyquinolines / chemistry*
  • Hydroxyquinolines / pharmacology*
  • Microbial Sensitivity Tests
  • Ruthenium / chemistry*
  • Ruthenium / pharmacology*
  • Salmonella / drug effects
  • Staphylococcus aureus / drug effects

Substances

  • Anti-Bacterial Agents
  • Coordination Complexes
  • Hydroxyquinolines
  • Ruthenium