Obsessive-compulsive symptom severity in schizophrenia: a Janus Bifrons effect on functioning

Eur Arch Psychiatry Clin Neurosci. 2016 Feb;266(1):63-9. doi: 10.1007/s00406-015-0608-y. Epub 2015 Jun 6.

Abstract

The impact of obsessive-compulsive symptoms on functioning in schizophrenia is still debated. This study investigated the relationship between OC symptoms and functioning along a severity gradient of obsessive-compulsive dimension. Sixty patients affected by schizophrenia completed the SCID-IV, the Positive and Negative Syndrome Scale, the Yale-Brown Obsessive-Compulsive Scale and the Social and Occupational Functioning Assessment Scale. The relationship between functioning and obsessive-compulsive dimension was described by a reverse U-shaped curve; functioning was positively related to the presence of mild obsessive-compulsive symptoms and inversely related to moderate and severe symptoms, after controlling for the severity of positive, negative, disorganization and general psychopathological symptoms. The role of obsessive-compulsive symptoms on social functioning in schizophrenia occurs along a severity continuum with a gradual transition from a positive correlation (from absent to mild symptoms) to an inverse correlation (for symptoms ranging from moderate to severe) and independently from schizophrenia symptom dimensions.

Keywords: Dimension; Functioning; Obsessive–compulsive symptoms; Positive and negative symptoms; Schizophrenia.

MeSH terms

  • Adult
  • Antipsychotic Agents / therapeutic use
  • Employment
  • Female
  • Humans
  • Male
  • Middle Aged
  • Obsessive-Compulsive Disorder / drug therapy
  • Obsessive-Compulsive Disorder / etiology*
  • Obsessive-Compulsive Disorder / psychology*
  • Psychiatric Status Rating Scales
  • Schizophrenia / complications*
  • Schizophrenia / drug therapy
  • Schizophrenic Psychology*
  • Social Behavior
  • Statistics, Nonparametric

Substances

  • Antipsychotic Agents