C21 steroidal glycosides from the roots of Cynanchum saccatum

Mi Zhang; Li-Li Rao; Cheng Xiang; Bao-Cai Li; Peng Li

doi:10.1016/j.steroids.2015.05.009

C21 steroidal glycosides from the roots of Cynanchum saccatum

Steroids. 2015 Sep:101:28-36. doi: 10.1016/j.steroids.2015.05.009. Epub 2015 Jun 3.

Authors

Mi Zhang¹, Li-Li Rao¹, Cheng Xiang¹, Bao-Cai Li², Peng Li³

Affiliations

¹ Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, China.
² Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, China. Electronic address: baocaili@hotmail.com.
³ State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Taipa, Macau 999078, China. Electronic address: pli1978@hotmail.com.

PMID: 26048447
DOI: 10.1016/j.steroids.2015.05.009

Abstract

Eight new C21 steroidal glycosides, named cynsaccatols A-H (1-8), along with two known analogs (9-10), were isolated from the roots of Cynanchum saccatum. Their structures were determined on the basis of detailed spectroscopic analysis, as well as HRESIMS. All compounds (1-10) were tested for their cytotoxicity in vitro using three human cancer cell lines (HepG2, Hela and U251), and compounds 1, 4, 5, 9, 10 showed weak inhibitory activities against different cell lines, respectively.

Keywords: Bioactivity; C(21) steroidal glycosides; Chemical constituent; Cynanchum saccatum; Cytotoxicity.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Agents / chemistry*
Antineoplastic Agents / isolation & purification
Antineoplastic Agents / pharmacology*
Cell Line, Tumor
Cynanchum / chemistry*
Glycosides / chemistry*
Glycosides / isolation & purification
Glycosides / pharmacology*
Humans
Plant Roots / chemistry*
Steroids / chemistry*

Substances

Antineoplastic Agents
Glycosides
Steroids