Abstract
A new series of imidazolyn-5-one derivatives were synthesized. These compounds were screened for their analgesic, anti-inflammatory and antipyretic activities, as well as for their ulcerogenic potential, for behavioural effects and acute toxicity. Some of them showed higher analgesic activity than phenylbutazone (PBZ), but lower anti-inflammatory activity. Their ulcerogenic effect was lesser than that of the reference drug.
MeSH terms
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Animals
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Anti-Inflammatory Agents, Non-Steroidal / chemical synthesis*
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Anti-Inflammatory Agents, Non-Steroidal / toxicity
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Behavior, Animal / drug effects
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Chemical Phenomena
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Chemistry
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Chromatography, Thin Layer
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Imidazoles / chemical synthesis*
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Imidazoles / pharmacology
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Imidazoles / toxicity
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Lethal Dose 50
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Mice
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Rats
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Rats, Inbred Strains
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Stomach Ulcer / chemically induced
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Stomach Ulcer / physiopathology
Substances
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Anti-Inflammatory Agents, Non-Steroidal
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Imidazoles