Dying mRNA Tells a Story of Its Life

Edward W J Wallace; D Allan Drummond

doi:10.1016/j.cell.2015.05.043

Dying mRNA Tells a Story of Its Life

Cell. 2015 Jun 4;161(6):1246-8. doi: 10.1016/j.cell.2015.05.043.

Authors

Edward W J Wallace¹, D Allan Drummond²

Affiliations

¹ Department of Biochemistry & Molecular Biology, The University of Chicago, Chicago, IL 60637, USA. Electronic address: ewallace@uchicago.edu.
² Department of Biochemistry & Molecular Biology, The University of Chicago, Chicago, IL 60637, USA. Electronic address: dadrummond@uchicago.edu.

PMID: 26046434
DOI: 10.1016/j.cell.2015.05.043

Abstract

In this issue of Cell, Pelechano et al. report that sequencing of mRNA decay intermediates shows surprisingly tight coupling of a major decay pathway to the movement of the last translating ribosome, revealing stress- and starvation-dependent modulation of translation elongation.

Publication types

Comment

MeSH terms

Protein Biosynthesis*
RNA Stability*
Ribosomes / metabolism*
Saccharomyces cerevisiae / metabolism*