[Drug-induced pancreatitis. A review of French spontaneous reports]

Rev Med Interne. 2015 Sep;36(9):573-8. doi: 10.1016/j.revmed.2015.04.012. Epub 2015 Jun 1.
[Article in French]

Abstract

Purpose: Identify the main pharmacological classes inducing pancreatitis using spontaneous reports recorded in the French pharmacovigilance database (FPVD).

Methods: Cases of pancreatitis recorded in FPVD between January 1st 1985 and December 31st 2013 were selected using the 2001 consensus conference criteria of the French High Health Authority.

Results: During this period, 2975 observations were selected with 1151 fulfilling criteria of drug-induced pancreatitis (i.e. 0.22% of total notifications in the FPVD). According to ATC classification, the pharmacological classes most frequently found were antiretroviral, analgesic, lipid-lowering, immunosuppressive and insulin secreting drugs. For some drugs (metformin, omeprazole, etc.) pancreatitis was "unlabelled" in the summary of product characteristics.

Conclusion: This review allows to identify the main drug classes currently involved in spontaneous reporting of pancreatitis in France.

Keywords: Adverse drug reactions; Drug-induced pancreatitis; Effets indésirables; Pancréatite médicamenteuse; Pharmacovigilance.

Publication types

  • English Abstract
  • Review

MeSH terms

  • Adverse Drug Reaction Reporting Systems* / standards
  • Adverse Drug Reaction Reporting Systems* / statistics & numerical data
  • Databases, Factual / standards
  • Databases, Factual / statistics & numerical data
  • Drug-Related Side Effects and Adverse Reactions / diagnosis
  • Drug-Related Side Effects and Adverse Reactions / epidemiology*
  • France / epidemiology
  • Humans
  • Pancreatitis / chemically induced*
  • Pharmaceutical Preparations / classification*
  • Pharmacovigilance*

Substances

  • Pharmaceutical Preparations