Synthesis of Nanogels via Cell Membrane-Templated Polymerization

Jianhua Zhang; Weiwei Gao; Ronnie H Fang; Anjie Dong; Liangfang Zhang

doi:10.1002/smll.201500987

Synthesis of Nanogels via Cell Membrane-Templated Polymerization

Small. 2015 Sep 9;11(34):4309-13. doi: 10.1002/smll.201500987. Epub 2015 Jun 5.

Authors

Jianhua Zhang^{1

2}, Weiwei Gao¹, Ronnie H Fang¹, Anjie Dong², Liangfang Zhang¹

Affiliations

¹ Department of Nanoengineering and Moores Cancer Center, University of California, San Diego, La Jolla, CA, 92093, USA.
² Department of Polymer Science and Engineering, School of Chemical Engineering and Technology, Tianjin University, Tianjin, 300072, China.

Abstract

The synthesis of biomimetic hydrogel nanoparticles coated with a natural cell membrane is described. Compared to the existing strategy of wrapping cell membranes onto pre-formed nanoparticle substrates, this new approach forms the cell membrane-derived vesicles first, followed by growing nanoparticle cores in situ. It adds significant controllability over the nanoparticle properties and opens unique opportunities for a broad range of biomedical applications.

Keywords: cell membranes; in situ polymerization; macromolecular inhibitors; nanogel; red blood cells.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Animals
Cyclic N-Oxides / chemical synthesis
Cyclic N-Oxides / chemistry
Erythrocyte Membrane / metabolism*
Erythrocyte Membrane / ultrastructure
Male
Mice, Inbred ICR
Nanogels
Polyethylene Glycols / chemical synthesis*
Polyethylene Glycols / chemistry
Polyethyleneimine / chemical synthesis*
Polyethyleneimine / chemistry
Polymerization*

Substances

Cyclic N-Oxides
Nanogels
polyethylene glycol polyethyleneimine nanogel
Polyethylene Glycols
Polyethyleneimine
TEMPO

Abstract

Publication types

MeSH terms

Substances

Grants and funding