Smart drug-loaded polymer gold nanoshells for systemic and localized therapy of human epithelial cancer

Jaemoon Yang; Jaewon Lee; Jinyoung Kang; Seung Jae Oh; Hyun-Ju Ko; Joo-Hiuk Son; Kwangyeol Lee; Jin-Suck Suh; Yong-Min Huh; Seungjoo Haam

doi:10.1002/adma.200900334

Smart drug-loaded polymer gold nanoshells for systemic and localized therapy of human epithelial cancer

Adv Mater. 2009 Nov 20;21(43):4339-42. doi: 10.1002/adma.200900334. Epub 2009 Jun 24.

Authors

Jaemoon Yang^{1

2}, Jaewon Lee², Jinyoung Kang², Seung Jae Oh^{1

3}, Hyun-Ju Ko¹, Joo-Hiuk Son⁴, Kwangyeol Lee⁵, Jin-Suck Suh¹, Yong-Min Huh⁶, Seungjoo Haam⁷

Affiliations

¹ Department of Radiology Yonsei University Seoul, 120-752 (Republic of Korea).
² Department of Chemical and Biomolecular Engineering Yonsei University Seoul, 120-749 (Republic of Korea).
³ Brain Korea 21 Project for Medical Science Yonsei University Seoul, 120-749 (Republic of Korea).
⁴ Department of Physics University of Seoul Seoul, 130-743 (Republic of Korea).
⁵ Department of Chemistry, Korea University Seoul 136-701 (Republic of Korea).
⁶ Department of Radiology Yonsei University Seoul, 120-752 (Republic of Korea). ymhuh@yuhs.ac.
⁷ Department of Chemical and Biomolecular Engineering Yonsei University Seoul, 120-749 (Republic of Korea). haam@yonsei.ac.kr.

PMID: 26042940
DOI: 10.1002/adma.200900334

Abstract

Near-infrared-light-sensitive multifunctional smart drug-loaded polymer gold nanoshells are fabricated as advanced prototypes, composed of chemotherapeutic agents (therapeutic antibody and anticancer drug-loaded polymeric nanoparticles) for systemic chemotherapy of human epithelial cancer and a polymer-based gold nanoshell for localized photothermal treatment by NIR light.

Keywords: cancer; drug load; gold nanoshells; near infrared; polymer.