Controllable release from high-transition temperature magnetoliposomes by low-level magnetic stimulation

Romina Spera; Francesca Apollonio; Micaela Liberti; Alessandra Paffi; Caterina Merla; Rosanna Pinto; Stefania Petralito

doi:10.1016/j.colsurfb.2015.04.030

Controllable release from high-transition temperature magnetoliposomes by low-level magnetic stimulation

Colloids Surf B Biointerfaces. 2015 Jul 1:131:136-40. doi: 10.1016/j.colsurfb.2015.04.030. Epub 2015 Apr 20.

Authors

Romina Spera¹, Francesca Apollonio², Micaela Liberti², Alessandra Paffi², Caterina Merla³, Rosanna Pinto³, Stefania Petralito⁴

Affiliations

¹ Department of Drug Chemistry and Technology, "Sapienza" University of Rome, P.le Aldo Moro 5, 00185 Rome, Italy.
² Department of Information Engineering, Electronics and Telecommunications, "Sapienza" University of Rome, Via Eudossiana 18, 00184 Rome, Italy.
³ Technical Unit of Radiation Biology and Human Health, Enea Research Center, Via Anguillarese 301, 00123 Rome, Italy.
⁴ Department of Drug Chemistry and Technology, "Sapienza" University of Rome, P.le Aldo Moro 5, 00185 Rome, Italy. Electronic address: stefania.petralito@uniroma1.it.

PMID: 26042528
DOI: 10.1016/j.colsurfb.2015.04.030

Abstract

High-transition temperature liposomes with embedded coated magnetite nanoparticles were prepared using the thin lipid film hydration method in order to obtain magnetoliposomes not sensitive to temperature increase (at least up to 50°C). Accordingly, drug can be released from such magnetoliposomes using a low-level electromagnetic field as triggering agent, while no delivery would be obtained with temperature increase within the physiological acceptable range. The hypothesized release mechanism involves mechanical stress of the liposome membrane due to nanoparticles oscillations and it is investigated by means of a numerical model evaluated using multiphysics simulations. The carrier content was repetitively released by switching on and off a 20kHz, 60A/m magnetic field. The results indicated high reproducibility of cycle-to-cycle release induced by the magnetic-impelled motions driving to the destabilization of the bilayer rather than the liposome phase transition or the destruction of the liposome structure.

Keywords: Alternating magnetic field; Drug delivery; High-transition temperature magnetoliposomes; Stimuli-responsive carriers.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Algorithms
Calorimetry, Differential Scanning
Electric Conductivity
Hot Temperature
Lipids / chemistry
Liposomes / chemistry*
Magnetic Fields
Magnetics*
Magnetite Nanoparticles / chemistry*
Models, Chemical
Spectrophotometry
Static Electricity
Transition Temperature*

Substances

Lipids
Liposomes
Magnetite Nanoparticles