Analysis of caffeine and paraxanthine in human saliva with ultra-high-performance liquid chromatography for CYP1A2 phenotyping

J Chromatogr B Analyt Technol Biomed Life Sci. 2015 Jul 15:995-996:70-3. doi: 10.1016/j.jchromb.2015.05.020. Epub 2015 May 18.

Abstract

Cytochrome P450 1A2 (CYP1A2) plays an important role in drug metabolism. Caffeine (CAF) is converted into paraxanthine (PX) by this enzyme and is used as a xenobiotic substrate to determine the CYP1A2 phenotype in humans. A method for the quantification of CAF and PX in saliva was developed using liquid-liquid extraction with ethyl acetate and analysis with ultra-high-performance liquid chromatography. Peaks from CAF, PX and internal standard were resolved within 6min. The method was validated from 0.05 to 5μgmL(-1) CAF and 0.025-2.5μgmL(-1) PX. Inter- and intra-day accuracies ranged from 91.2 to 107.2% with precisions <13.5%. The limits of detection were 0.16 and 0.63 ngmL(-1) for PX and CAF, respectively. PX/CAF concentration ratios from volunteers were 0.26-1.09 with mean ratios of 0.78±0.26 and 0.38±0.10 for regular and light/non-coffee drinkers, respectively.

Keywords: CYP1A2; Caffeine; Paraxanthine; Phenotyping; Saliva; UHPLC.

MeSH terms

  • Caffeine / analysis*
  • Caffeine / metabolism
  • Chromatography, High Pressure Liquid / methods*
  • Cytochrome P-450 CYP1A2 / classification*
  • Cytochrome P-450 CYP1A2 / metabolism
  • Humans
  • Linear Models
  • Phenotype
  • Reproducibility of Results
  • Saliva / chemistry*
  • Sensitivity and Specificity
  • Theophylline / analysis*
  • Theophylline / metabolism

Substances

  • Caffeine
  • Theophylline
  • CYP1A2 protein, human
  • Cytochrome P-450 CYP1A2
  • 1,7-dimethylxanthine