Multifunctional inverse opal particles for drug delivery and monitoring

Nanoscale. 2015 Jun 28;7(24):10590-4. doi: 10.1039/c5nr02324f. Epub 2015 Jun 2.

Abstract

Particle-based delivery systems have a demonstrated value for drug discovery and development. Here, we report a new type of particle-based delivery system that has controllable release and is self-monitoring. The particles were composed of poly(N-isopropylacrylamide) (pNIPAM) hydrogel with an inverse opal structure. The presence of macropores in the particles provides channels for active drug loading and release from the materials.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acrylic Resins / chemistry*
  • Contrast Media / chemical synthesis*
  • Delayed-Action Preparations / chemical synthesis*
  • Diffusion
  • Drug Monitoring / methods*
  • Microscopy, Fluorescence / methods
  • Nanocapsules / administration & dosage
  • Nanocapsules / chemistry*
  • Nanocapsules / ultrastructure
  • Particle Size
  • Theranostic Nanomedicine / methods

Substances

  • Acrylic Resins
  • Contrast Media
  • Delayed-Action Preparations
  • Nanocapsules
  • poly-N-isopropylacrylamide