A new subgenotype 2.1d isolates of classical swine fever virus in China, 2014

Infect Genet Evol. 2015 Aug:34:94-105. doi: 10.1016/j.meegid.2015.05.031. Epub 2015 May 29.

Abstract

The lapinized attenuated vaccine against classical swine fever (CSF) has been used in China for over half a century and has generally prevented large-scale outbreaks in recent years. However, since late 2014, a large number of new cases of CSF were detected in many immunized pig farms in China. Several of these CSV viruses were isolated and characterized. Phylogenetic and genomic sequence analyses indicate that these new isolates, as well as some reference isolates, form a new subgenotype named 2.1d, and share several consistent molecular characteristics. Since these new isolates emerged in disparate geographic regions within 5 months, this suggests that these isolates may be widespread. Given that current vaccines do not appear to provide effective protection against this new subgenotype, further investigation of these strains is urgently needed.

Keywords: Classical swine fever virus; E2; New subgenotype.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • China / epidemiology
  • Classical Swine Fever / epidemiology
  • Classical Swine Fever / virology*
  • Classical Swine Fever Virus / genetics*
  • Classical Swine Fever Virus / isolation & purification
  • Disease Outbreaks*
  • Genome, Viral
  • Genotype
  • Molecular Sequence Data
  • Phylogeny
  • Sequence Analysis, DNA
  • Sus scrofa / virology
  • Swine
  • Viral Proteins / chemistry
  • Viral Proteins / genetics

Substances

  • Viral Proteins