Excitatory transmission at thalamo-striatal synapses mediates susceptibility to social stress

Daniel J Christoffel; Sam A Golden; Jessica J Walsh; Kevin G Guise; Mitra Heshmati; Allyson K Friedman; Aditi Dey; Milo Smith; Nicole Rebusi; Madeline Pfau; Jessica L Ables; Hossein Aleyasin; Lena A Khibnik; Georgia E Hodes; Gabriel A Ben-Dor; Karl Deisseroth; Matthew L Shapiro; Robert C Malenka; Ines Ibanez-Tallon; Ming-Hu Han; Scott J Russo

doi:10.1038/nn.4034

Excitatory transmission at thalamo-striatal synapses mediates susceptibility to social stress

Nat Neurosci. 2015 Jul;18(7):962-4. doi: 10.1038/nn.4034. Epub 2015 Jun 1.

Authors

Daniel J Christoffel¹, Sam A Golden², Jessica J Walsh³, Kevin G Guise², Mitra Heshmati², Allyson K Friedman⁴, Aditi Dey², Milo Smith², Nicole Rebusi², Madeline Pfau², Jessica L Ables⁵, Hossein Aleyasin², Lena A Khibnik², Georgia E Hodes², Gabriel A Ben-Dor⁶, Karl Deisseroth⁷, Matthew L Shapiro², Robert C Malenka⁶, Ines Ibanez-Tallon⁵, Ming-Hu Han³, Scott J Russo²

Affiliations

¹ 1] Fishberg Department of Neuroscience, Friedman Brain Institute Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA. [2] Nancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, California, USA.
² Fishberg Department of Neuroscience, Friedman Brain Institute Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
³ 1] Fishberg Department of Neuroscience, Friedman Brain Institute Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA. [2] Department of Pharmacology and Systems Therapeutics, Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
⁴ Department of Pharmacology and Systems Therapeutics, Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
⁵ Laboratory of Molecular Genetics, Howard Hughes Medical Institute, Rockefeller University, New York, New York, USA.
⁶ Nancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, California, USA.
⁷ 1] Nancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, California, USA. [2] Department of Bioengineering, Stanford University, Stanford, California, USA.

PMID: 26030846
PMCID: PMC4482771
DOI: 10.1038/nn.4034

Abstract

Postsynaptic remodeling of glutamatergic synapses on ventral striatum (vSTR) medium spiny neurons (MSNs) is critical for shaping stress responses. However, it is unclear which presynaptic inputs are involved. Susceptible mice exhibited increased synaptic strength at intralaminar thalamus (ILT), but not prefrontal cortex (PFC), inputs to vSTR MSNs following chronic social stress. Modulation of ILT-vSTR versus PFC-vSTR neuronal activity differentially regulated dendritic spine plasticity and social avoidance.

Publication types

Research Support, N.I.H., Extramural

MeSH terms

Animals
Behavior, Animal / physiology
Dendritic Spines / physiology*
Disease Susceptibility
Excitatory Postsynaptic Potentials / physiology*
Male
Mice
Mice, Inbred C57BL
Neuronal Plasticity / physiology*
Prefrontal Cortex / physiology*
Reward
Social Behavior
Stress, Psychological / physiopathology*
Thalamus / physiology*
Ventral Striatum / cytology
Ventral Striatum / physiology*

Abstract

Publication types

MeSH terms

Grants and funding