Differential genomic damage in different tumor lines induced by prodigiosin

Anticancer Res. 2015 Jun;35(6):3325-32.

Abstract

Prodigiosin is a secondary metabolite produced by Serratia marcercens. As this pigment is suggested to be a cancer drug, genotoxicity studies are necessary. The aim of the present investigation was to evaluate the genotoxic effects of prodigiosin on tumoral and normal cell lines, NCIH-292, MCF-7 and HL-60. A normal line BGMK was used as control. Genomic damage induced by prodigiosin was observed in all tumor lines as well as the control line. The pigment induced the formation of micronuclei in tumor cells. The present data confirm the antitumor potential of prodigiosin. However, these findings also raise concerns regarding its target-specific action, as genotoxic effects on normal cells also occurred.

Keywords: genotoxicity; micronucleus; prodigiosin; tumor cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • DNA Damage / drug effects*
  • Genome, Human / drug effects*
  • Humans
  • MCF-7 Cells
  • Neoplasms / drug therapy*
  • Neoplasms / pathology
  • Prodigiosin / administration & dosage*
  • Prodigiosin / adverse effects
  • Serratia / chemistry
  • Serratia / pathogenicity
  • Serratia Infections / complications
  • Serratia Infections / drug therapy
  • Serratia Infections / genetics

Substances

  • Prodigiosin