Detection of boronic acid derivatives in cells using a fluorescent sensor

Org Biomol Chem. 2015 Jul 7;13(25):6927-30. doi: 10.1039/c5ob00753d. Epub 2015 May 29.

Abstract

The detection of boron-containing compounds requires very expensive facilities and/or tedious sample pretreatments. In an effort to develop a convenient detection method for boronic acid derivatives, boron chelating-ligands were synthesized for use as fluorescent sensors. In this paper, the synthesis and properties of fluorescent sensors for boronic acid derivatives are reported.

MeSH terms

  • Antineoplastic Agents / analysis*
  • Boron / chemistry*
  • Boron Compounds / analysis*
  • Boronic Acids / analysis*
  • Bortezomib / analysis*
  • Cell Line, Tumor
  • Chelating Agents / chemistry*
  • Fluorescent Dyes / chemistry*
  • Humans
  • Optical Imaging / methods
  • Phenylalanine / analogs & derivatives*
  • Phenylalanine / analysis
  • Spectrometry, Fluorescence / methods

Substances

  • Antineoplastic Agents
  • Boron Compounds
  • Boronic Acids
  • Chelating Agents
  • Fluorescent Dyes
  • Phenylalanine
  • Bortezomib
  • Boron
  • 4-boronophenylalanine