Synthetic trehalose esters of cis-alkene and diene α'-mycolic acids of Mycobacteria

Salam G Taher; Maged Muzael; Juma'a R Al Dulayymi; Mark S Baird

doi:10.1016/j.chemphyslip.2015.05.004

Synthetic trehalose esters of cis-alkene and diene α'-mycolic acids of Mycobacteria

Chem Phys Lipids. 2015 Jul:189:28-38. doi: 10.1016/j.chemphyslip.2015.05.004. Epub 2015 May 27.

Authors

Salam G Taher¹, Maged Muzael¹, Juma'a R Al Dulayymi¹, Mark S Baird²

Affiliations

¹ School of Chemistry, Bangor University, Bangor, Gwynedd, UK LL57 2UW.
² School of Chemistry, Bangor University, Bangor, Gwynedd, UK LL57 2UW. Electronic address: chs028@bangor.ac.uk.

PMID: 26022243
DOI: 10.1016/j.chemphyslip.2015.05.004

Abstract

The synthesis of an α'-mycolic acid of Mycobacterium smegmatis and other mycobacteria, containing a cis,cis-diene, and of the trehalose mono- and di-mycolates of this, and of a related α'-mycolic acid containing one cis-alkene, is reported.

Keywords: Cord factor; TDM; TMM; cis-Alkene; α’-Mycolic acid.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Alkenes / chemistry*
Esters
Isomerism
Magnetic Resonance Spectroscopy
Mycobacterium / chemistry
Mycobacterium / metabolism
Mycolic Acids / chemistry*
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
Trehalose / chemical synthesis
Trehalose / chemistry*

Substances

Alkenes
Esters
Mycolic Acids
Trehalose