Phthalein dyes in the quinone dianion form (pseudo-D3, colored) are transformed into the lactone dianion form (pseudo-T(d), colorless) through encapsulation in a T(d)-symmetric host even under basic conditions (pH ∼10). The compatibility in size and symmetry between the lactone and the cavity is essential to the transformation. Upon addition of a guest that strongly binds to the cavity, the encapsulated phenolphthalein is expelled, the color of the basic solution is regained, and the host-guest complexation is thus visualized.