Abstract
Bioassay-guided fractionation of an EtOH extract of the roots of the plant Apoplanesia paniculata (Fabaceae) led to the isolation of the three known compounds amorphaquinone (1), pendulone (2), and melilotocarpan C (3), and the two new pterocarpans 4 and 5. Compounds 1 and 2 exhibited good antiplasmodial activity with IC50 values of 5.7 ± 1.5 and 7.0 ± 0.8 µM, respectively. Compound 3 exhibited weak antiplasmodial activity (41.8 ± 5.2 µM), while compounds 4 and 5 were inactive. Compound 6 was synthesized to confirm the structure of 5, and it showed enhanced antiplasmodial activity (15.8 ± 1.4 µM) compared to its analogues 3-5.
Georg Thieme Verlag KG Stuttgart · New York.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Antimalarials / chemistry*
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Antimalarials / isolation & purification
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Antimalarials / pharmacology
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Cell Line, Tumor
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Fabaceae / chemistry*
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Female
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Humans
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Isoflavones / chemistry
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Isoflavones / isolation & purification
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Isoflavones / pharmacology
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Molecular Structure
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Plant Extracts / chemistry*
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Plant Extracts / isolation & purification
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Plant Extracts / pharmacology
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Plant Roots / chemistry
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Plasmodium falciparum / drug effects*
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Pterocarpans / chemistry*
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Pterocarpans / isolation & purification
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Pterocarpans / pharmacology
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Quinones / chemistry
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Quinones / isolation & purification
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Quinones / pharmacology
Substances
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Antimalarials
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Isoflavones
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Plant Extracts
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Pterocarpans
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Quinones
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amorphaquinone
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pendulone