The Relationship Between Water Structure and Blood Compatibility in Poly(2-methoxyethyl Acrylate) (PMEA) Analogues

Kazuhiro Sato; Shingo Kobayashi; Miho Kusakari; Shogo Watahiki; Masahiko Oikawa; Takashi Hoshiba; Masaru Tanaka

doi:10.1002/mabi.201500078

The Relationship Between Water Structure and Blood Compatibility in Poly(2-methoxyethyl Acrylate) (PMEA) Analogues

Macromol Biosci. 2015 Sep;15(9):1296-303. doi: 10.1002/mabi.201500078. Epub 2015 May 28.

Authors

Kazuhiro Sato¹, Shingo Kobayashi^{1

2}, Miho Kusakari¹, Shogo Watahiki¹, Masahiko Oikawa¹, Takashi Hoshiba^{1

3}, Masaru Tanaka^{4

5}

Affiliations

¹ Department of Biochemical Engineering, Graduate School of Science and Engineering, Yamagata University, 4-3-16 Jonan, Yonezawa, Yamagata, 992-8510, Japan.
² Institute for Materials Chemistry and Engineering, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka, 819-0395, Japan.
³ International Center for Materials Nanoarchitectonics (MANA), National Institute for Materials Science, 1-1 Namiki, Tsukuba, Ibaraki, 305-0044.
⁴ Department of Biochemical Engineering, Graduate School of Science and Engineering, Yamagata University, 4-3-16 Jonan, Yonezawa, Yamagata, 992-8510, Japan. tanaka@yz.yamagata-u.ac.jp.
⁵ Institute for Materials Chemistry and Engineering, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka, 819-0395, Japan. tanaka@yz.yamagata-u.ac.jp.

PMID: 26017931
DOI: 10.1002/mabi.201500078

Abstract

Six types of poly(2-methoxyethyl acrylate) (PMEA) analogues were synthesized and the water structure in the hydrated polymers was characterized using differential scanning calorimetry (DSC). The hydrated PMEA analogues exhibited the different amounts of intermediate water. Non-thrombogenicity evaluation was performed on PMEA analogues for platelet adhesion and protein adsorption. Platelet adhesion was suppressed on PMEA analogues. In addition, the protein adsorption and deformation were suppressed by increasing the amount of intermediate water. This study demonstrates that the amount of intermediate water might play a key role in expressing the blood compatibility of polymeric materials.

Keywords: biomaterial; blood compatibility; intermediate water; protein adsorption; water structure.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Acrylates / chemistry*
Acrylates / pharmacology*
Adsorption
Biocompatible Materials*
Blood
Calorimetry, Differential Scanning
Humans
Platelet Adhesiveness / drug effects*
Polymers / chemistry*
Polymers / pharmacology*
Proteins / chemistry
Water / chemistry*

Substances

Acrylates
Biocompatible Materials
Polymers
Proteins
poly(2-methoxyethylacrylate)
Water