Treating skin diseases according to the low dose medicine principles. Data and hypotheses

T Lotti; J Hercogova; U Wollina; A A Chokoeva; Z Zarrab; S Gianfaldoni; M G Roccia; M Fioranelli; G Tchernev

Treating skin diseases according to the low dose medicine principles. Data and hypotheses

J Biol Regul Homeost Agents. 2015 Jan-Mar;29(1 Suppl):47-51.

Authors

T Lotti¹, J Hercogova², U Wollina³, A A Chokoeva⁴, Z Zarrab⁵, S Gianfaldoni⁶, M G Roccia⁷, M Fioranelli⁸, G Tchernev⁴

Affiliations

¹ Professor and Chair of Dermatology, University of Rome G.Marconi, Rome, Italy.
² Dept. Dermatology, 2nd Medical School, Charles University, Prague.
³ Department of Dermatology and Allergology, Academic Teaching Hospital Dresden-Friedrichstadt, Dresden, Germany.
⁴ Onkoderma-Policlinic for Dermatology, Venereology and Dermatologic surgery, Sofia, Bulgaria.
⁵ University of Rome G. Marconi, Rome, Italy.
⁶ Department of dermatologic Sciences, University of Florence, Florence, Italy.
⁷ Chandigarh University, Punjab, India.
⁸ Associate Professor of Physiology, University B.I.S. Group of Institutions, Punjab Technical University, Punjab, India.

PMID: 26016968

Abstract

Cytokines, hormones and growth factors, also defined with the collective name of signaling molecules are key regulating agents of physiological (and also pathological) functions according to the principles of Psycho-Neuro-Endocrine-Immunology (P.N.E.I.). From the latest evidences in the fields of Molecular Biology, P.N.E.I. and nano-concentration, a new medical approach surfaces: the Low Dose Medicine (LDM), a new tool for the study and the design of therapeutic strategies based on immune rebalance interventions. LDM suggest the use of low-doses of activated signaling molecules in order to restore P.N.E.I. homeostatic conditions and an increasing number of scientific evidences of LDM approach efficacy and safety support LDM-based therapeutic approach for the treatment of many dermatological diseases such as Psoriasis Vulgaris, Vitiligo and Atopic Dermatitis.