Synthesis and in vitro Screening of 29, 30-Dibromo-28-oxoallobetulin against Parasitic Protozoans, Leishmania donovani and Leishmania Major

P Ghosh; A Mandal; S Dey; C Pal

doi:10.4103/0250-474x.156596

Synthesis and in vitro Screening of 29, 30-Dibromo-28-oxoallobetulin against Parasitic Protozoans, Leishmania donovani and Leishmania Major

Indian J Pharm Sci. 2015 Mar-Apr;77(2):202-7. doi: 10.4103/0250-474x.156596.

Authors

P Ghosh¹, A Mandal¹, S Dey², C Pal²

Affiliations

¹ Natural Products and Polymer Chemistry Laboratory, Department of Chemistry, University of North Bengal, Raja Rammhunpur, Darjeeling-734 013, India.
² Cellular Immunology and Experimental Therapeutics Laboratory, Department of Zoology, West Bengal State University, Barasat-700 126, India.

Abstract

A simple synthesis and in vitro antileishmanial activity of 29,30-dibromo-28-oxoallobetulin against the parasitic protozoans, Leishmania donovani and Leishmania major is described. The structure of the compound is established on the basis of spectral data (IR, NMR, MS). Both the antiproliferative effect and the cell cycle progression were studied.

Keywords: Triterpenoid; antiproliferative; halogen; leishmania.