Arteriolar thrombosis is a complication that may occur during systemic lupus erithematosus. The pathophysiology could be related to abnormal endothelial function secondary to immune dysregulation. In particular renal and intestinal vessels may be target of thrombosis. We report a simultaneous appearance of lupus nephritis and enteritis in a young female who presented with renal failure and proteinuria. The presence of renal arteriolar thrombosis together with intestinal ischemia lead us to speculate a possible common pathways.