Abstract
5-Fluoro-2,1-benzoxaborol-1(3H)-ol, a potent antifungal drug also known as Tavaborole or AN2690, has been compared with its three isomers in terms of its activity against several fungi as well as pKa and multinuclear NMR characterization. The molecular and crystal structure of 6-fluoro-2,1-benzoxaborol-1(3H)-ol was determined and compared with that of AN2690.
Keywords:
Antifungal activity; Benzoxaboroles; Crystal structure; Tavaborole.
Copyright © 2015 Elsevier Inc. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antifungal Agents / chemistry*
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Antifungal Agents / pharmacology*
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Boron Compounds / chemistry*
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Boron Compounds / pharmacology*
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Bridged Bicyclo Compounds, Heterocyclic / chemistry*
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Bridged Bicyclo Compounds, Heterocyclic / pharmacology*
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Crystallography, X-Ray
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Fluorine / chemistry*
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Fluorine / pharmacology*
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Fungi / drug effects*
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Halogenation
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Humans
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Isomerism
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Magnetic Resonance Spectroscopy
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Models, Molecular
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Mycoses / drug therapy
Substances
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Antifungal Agents
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Boron Compounds
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Bridged Bicyclo Compounds, Heterocyclic
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Fluorine
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tavaborole