Anticancer activity of Cinnamon tamala leaf constituents towards human ovarian cancer cells

Durre Shahwar; Sami Ullah; Mohammad Akmal Khan; Naeem Ahmad; Afifa Saeed; Saif Ullah

Anticancer activity of Cinnamon tamala leaf constituents towards human ovarian cancer cells

Pak J Pharm Sci. 2015 May;28(3):969-72.

Authors

Durre Shahwar¹, Sami Ullah², Mohammad Akmal Khan¹, Naeem Ahmad¹, Afifa Saeed¹, Saif Ullah¹

Affiliations

¹ Research Lab. II, Department of Chemistry, GC University, Lahore, Pakistan.
² Research Lab. II, Department of Chemistry, GC University, Lahore, Pakistan / Department of Chemistry, University of Gujrat, Hafiz Hayat Campus, Gujrat, Pakistan.

PMID: 26004731

Abstract

Bioassay guided fractionation of Cinnamon tamala leaf extracts yielded bornyl acetate (1), caryophylene oxide (2), p-coumaric acid (3) and vanillic acid (4) using A-2780 human ovarian cancer cell lines. The structures of the isolated compounds were confirmed through spectroscopic techniques (EIMS, (1)H and (13)C NMR). Compound 1 exhibited highest cytotoxicity with 90.16 ± 1.06% inhibition (IC50=5.30 x 10(-4) mg/ml) followed by compound 2 (84.40±1.53% inhibition; IC50=8.94 x 10(-3)mg/ml), while compounds 3 and 4 were inactive in the bioassay.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antineoplastic Agents, Phytogenic / pharmacology*
Camphanes / pharmacology
Carcinoma*
Cell Line, Tumor
Cell Proliferation / drug effects*
Cell Survival / drug effects
Cinnamomum*
Coumaric Acids / pharmacology
Cricetinae
Drug Screening Assays, Antitumor
Female
Humans
Ovarian Neoplasms*
Plant Extracts / chemistry
Plant Extracts / pharmacology*
Plant Leaves
Polycyclic Sesquiterpenes
Propionates
Sesquiterpenes / pharmacology
Vanillic Acid / pharmacology

Substances

Antineoplastic Agents, Phytogenic
Camphanes
Coumaric Acids
Plant Extracts
Polycyclic Sesquiterpenes
Propionates
Sesquiterpenes
bornyl acetate
Vanillic Acid
p-coumaric acid
caryophyllene oxide