A CRISPR View of Cleavage

Ariel D Weinberger; Michael S Gilmore

doi:10.1016/j.cell.2015.05.003

A CRISPR View of Cleavage

Cell. 2015 May 21;161(5):964-966. doi: 10.1016/j.cell.2015.05.003.

Authors

Ariel D Weinberger¹, Michael S Gilmore²

Affiliations

¹ Wyss Institute for Biologically Inspired Engineering, Harvard Medical School, Boston, MA 02115, USA. Electronic address: ariel.weinberger@wyss.harvard.edu.
² Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA 02115, USA; Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115, USA.

PMID: 26000476
DOI: 10.1016/j.cell.2015.05.003

Abstract

Seminal studies showed that CRISPR-Cas systems provide adaptive immunity in prokaryotes and promising gene-editing tools from bacteria to humans. Yet, reports diverged on whether some CRISPR systems naturally target DNA or RNA. Here, Samai and colleagues unify the studies, showing that a single type III CRISPR-Cas system cleaves both DNA and RNA targets, independently.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Comment

MeSH terms

CRISPR-Cas Systems*
Staphylococcus epidermidis / metabolism*

Abstract

Publication types

MeSH terms

Grants and funding