The relation between platelet-to-lymphocyte ratio and Pulmonary Embolism Severity Index in acute pulmonary embolism

Heart Lung. 2015 Jul-Aug;44(4):340-3. doi: 10.1016/j.hrtlng.2015.04.007. Epub 2015 May 18.

Abstract

Purpose: In this study, we aimed to investigate the value of the platelet-to-lymphocyte ratio (PLR) for predicting disease severity based on simplified Pulmonary Embolism Severity Index (sPESI), as well as in-hospital mortality in patients with acute pulmonary embolism (APE).

Materials and methods: Our hospital's electronic patient database was searched for the patients with ICD-9 code I26, and eligible 646 patients were included in the study.

Results: Univariate logistic regression analysis showed that PLR, pulmonary artery systolic pressure, right ventricular dysfunction, D-dimer level, and white blood cell, lymphocyte, platelet and neutrophil counts were significantly correlated with a high sPESI score in patients with APE.

Conclusions: To the best of our knowledge, this is the first study in the literature showing that a high PLR is independently associated with a high risk of mortality in patients with APE.

Keywords: Acute pulmonary embolism; Inflammation; Platelet function; Platelet-lymphocyte ratio; Simplified pulmonary embolism severity.

Publication types

  • Clinical Study

MeSH terms

  • Acute Disease
  • Blood Platelets*
  • Female
  • Fibrin Fibrinogen Degradation Products / metabolism
  • Hospital Mortality
  • Humans
  • Lymphocyte Count
  • Lymphocytes*
  • Male
  • Middle Aged
  • Neutrophils
  • Platelet Count
  • Prognosis
  • Pulmonary Embolism / pathology*
  • ROC Curve
  • Risk Factors
  • Severity of Illness Index
  • Ventricular Dysfunction, Right / pathology

Substances

  • Fibrin Fibrinogen Degradation Products
  • fibrin fragment D