Toxicity identification evaluation (TIE) was applied to the effluent from a pharmaceutical industrial complex, following the US EPA TIE guidelines. The whole effluent toxicity (WET) test found toxicity greater than 16toxic units (TU) in the effluent. Dissolved non-polar organic compounds were identified as the major contributor to the observed toxicity in the TIE manipulations in phases I and II. Among the 48 organic compounds identified, three compounds (i.e., acetophenone, benzoimide, and benzothiazole) were related to the pharmaceutical production procedure; however, no contribution to toxicity was predicted in the compounds. The results of the ECOSAR model, which predicts toxicity, indicated that the alkane compounds caused significant toxicity in the effluent. The toxicity test and heavy metal analysis, which used IC and ICP/MS, identified that particulate and heavy metals, such as Cu and Zn, contributed to the remaining toxicity, except dissolved organics. The results showed the applicability of the TIE method for predicting regional effluents produced by the industrial pharmaceutical complex in this study. Although the location was assumed to be affected by discharge of pharmaceutical related compounds in the river, no correlations were observed in the study. Based on the results, advanced treatment processes, such as activated carbon adsorption, are recommended for the wastewater treatment process in this location.
Keywords: Effluents; Pharmaceutical; Toxicity identification evaluation (TIE).
Copyright © 2015 Elsevier Ltd. All rights reserved.