Self-assembly of amphiphilic anionic calix[4]arenes and encapsulation of poorly soluble naproxen and flurbiprofen

Org Biomol Chem. 2015 Jun 21;13(23):6468-73. doi: 10.1039/c5ob00703h. Epub 2015 May 21.

Abstract

Supramolecular aggregates formed through the association of an amphiphilic tetra-O-butylsulfonate calix[4]arene 1 were investigated in aqueous solution by a combination of different techniques (NMR, DLS and AFM). The ability of the micellar aggregates of calixarene 1 to increase the solubility of poorly water-soluble drugs was studied.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anions / chemistry
  • Calixarenes / chemistry*
  • Dynamic Light Scattering
  • Flurbiprofen / chemistry*
  • Magnetic Resonance Spectroscopy
  • Micelles
  • Microscopy, Atomic Force
  • Molecular Structure
  • Naproxen / chemistry*
  • Solubility
  • Surface-Active Agents / chemistry

Substances

  • Anions
  • Micelles
  • Surface-Active Agents
  • p-tert-butylcalix(4)arene tetra-O-butylsulfonate
  • Calixarenes
  • Naproxen
  • Flurbiprofen