An increasing prevalence of chronic diseases is observed, among which cancer is now included because of its survival rates. That trend requires new ways of supporting outpatients and improving their compliance to treatments. This paper introduces HeNeA, a mobile application designed to support patients affected by Head and Neck cancer during their treatments. The application leverages on the mHealth features described in the literature and has been reviewed by a small set of patients during its development. Further evaluation is expected to occur when it will be offered to every eligible patient discharged from the Head and Neck division of a major Italian cancer centre.