Strongylophorines, meroditerpenoids from the marine sponge Petrosia corticata, function as proteasome inhibitors

Bioorg Med Chem Lett. 2015 Jul 1;25(13):2650-3. doi: 10.1016/j.bmcl.2015.04.075. Epub 2015 Apr 30.

Abstract

Two new strongylophorine derivatives, along with six known strongylophorines, were isolated from the marine sponge Petrosia corticata as proteasome inhibitors. Of these, a hemiacetal mixture of strongylophorines-13/-14 was the strongest inhibitor of the proteasome with an IC50 of 2.1μM.

Keywords: Meroditerpenoid; Petrosia corticata; Proteasome inhibitor; Strongylophorine.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / isolation & purification
  • Antineoplastic Agents / pharmacology
  • Diterpenes / chemistry*
  • Diterpenes / isolation & purification
  • Diterpenes / pharmacology*
  • Drug Evaluation, Preclinical
  • Humans
  • Magnetic Resonance Spectroscopy
  • Petrosia / chemistry*
  • Proteasome Inhibitors / chemistry*
  • Proteasome Inhibitors / isolation & purification
  • Proteasome Inhibitors / pharmacology*
  • Spectrometry, Mass, Fast Atom Bombardment
  • Structure-Activity Relationship

Substances

  • Antineoplastic Agents
  • Diterpenes
  • Proteasome Inhibitors