Abstract
Two new strongylophorine derivatives, along with six known strongylophorines, were isolated from the marine sponge Petrosia corticata as proteasome inhibitors. Of these, a hemiacetal mixture of strongylophorines-13/-14 was the strongest inhibitor of the proteasome with an IC50 of 2.1μM.
Keywords:
Meroditerpenoid; Petrosia corticata; Proteasome inhibitor; Strongylophorine.
Copyright © 2015 Elsevier Ltd. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / isolation & purification
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Antineoplastic Agents / pharmacology
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Diterpenes / chemistry*
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Diterpenes / isolation & purification
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Diterpenes / pharmacology*
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Drug Evaluation, Preclinical
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Humans
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Magnetic Resonance Spectroscopy
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Petrosia / chemistry*
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Proteasome Inhibitors / chemistry*
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Proteasome Inhibitors / isolation & purification
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Proteasome Inhibitors / pharmacology*
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Spectrometry, Mass, Fast Atom Bombardment
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Structure-Activity Relationship
Substances
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Antineoplastic Agents
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Diterpenes
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Proteasome Inhibitors