Modulatory effects on dendritic cells by human herpesvirus 6

Rasmus Gustafsson; Mattias Svensson; Anna Fogdell-Hahn

doi:10.3389/fmicb.2015.00388

Modulatory effects on dendritic cells by human herpesvirus 6

Front Microbiol. 2015 Apr 30:6:388. doi: 10.3389/fmicb.2015.00388. eCollection 2015.

Authors

Rasmus Gustafsson¹, Mattias Svensson², Anna Fogdell-Hahn³

Affiliations

¹ Department of Molecular Medicine and Surgery, Karolinska Institutet, Karolinska University Hospital Stockholm, Sweden.
² Department of Medicine, Center for Infectious Medicine, Karolinska Institutet, Karolinska University Hospital Stockholm, Sweden.
³ Department of Clinical Neuroscience, Karolinska Institutet, Karolinska University Hospital Stockholm, Sweden.

Abstract

Human herpesvirus 6A and 6B are β-herpesviruses approaching 100% seroprevalance worldwide. These viruses are involved in several clinical syndromes and have important immunomodulatory effects. Dendritic cells (DC) are key players in innate and adaptive immunity. Accordingly, DC are implicated in the pathogenesis of many human diseases, including infections. In this review the effects of HHV-6 infection on DC will be discussed.

Keywords: HHV-6; HLA; activation; co-stimulatory molecules; cytokines; dendritic cells.

Publication types

Review