α-Aminoisobutyric Acid Leads a Fluorescent syn-bimane LASER Probe Across the Blood-brain Barrier

Med Chem. 2016;12(1):48-53. doi: 10.2174/1573406411666150518105010.

Abstract

Penetration of the blood brain barrier (BBB) by appropriate fluorescent probes remains a challenge in optical imaging and diagnostics. We designed, synthesized and observed the in vivo BBB penetration of a LASER syn-bimane probe. Results demonstrate that the Aib transporter unit in our probe may lead a fluorescent bimanyl moiety across the BBB.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aminoisobutyric Acids / chemical synthesis
  • Aminoisobutyric Acids / pharmacokinetics*
  • Animals
  • Azabicyclo Compounds / chemical synthesis
  • Azabicyclo Compounds / pharmacokinetics*
  • Blood-Brain Barrier / metabolism*
  • Bridged Bicyclo Compounds, Heterocyclic / chemical synthesis
  • Bridged Bicyclo Compounds, Heterocyclic / pharmacokinetics*
  • Fluorescent Dyes / chemical synthesis
  • Fluorescent Dyes / pharmacokinetics*
  • Male
  • Mice
  • Microscopy, Fluorescence
  • Tissue Distribution

Substances

  • Aminoisobutyric Acids
  • Azabicyclo Compounds
  • Bridged Bicyclo Compounds, Heterocyclic
  • Fluorescent Dyes
  • bimanes